Stem Cells
Stem cells are the fundamental components of the organism, possessing the capacity to self-renew and differentiate into various cell types. They can be found in embryonic, foetal, and adult stages.
Thanks to their self-renewal, differentiation, and proliferation properties, they play a critical role in tissue regeneration and repair.
Features
Self-renewal:
They can maintain their stem cell properties by dividing for long periods.
Potency (differentiation capacity):
They can exhibit totipotent, pluripotent, multipotent, or unipotent properties.
Tissue repair:
They play a role in the regeneration of damaged tissues.
Classification
Embryonic stem cells (ESCs):
They possess pluripotent properties and can differentiate into all cell types.
Adult stem cells (e.g. MSC):
They are multipotent and can differentiate into specific tissue types.
Induced pluripotent stem cells (iPSC):
They are obtained by genetically reprogramming somatic cells.
Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells derived from connective tissue with multipotent properties. They can differentiate into cells such as bone, cartilage, fat, muscle, and connective tissue.
They also possess immunomodulatory properties, regulating the immune system, suppressing inflammation, and supporting regenerative processes.
They are one of the most commonly used types of stem cells in clinical applications.
Their main features are:
- Migration: Migration to damaged tissue
- Fusion: Merging with damaged cells
- Differentiation: Differentiation into the cell they merge with
- Immunosuppression: Reduction of immune system activation
- Immunomodulation: Regulation of the immune system
Wharton’s Jelly-Derived Mesenchymal Stem Cells
(for Allogeneic use)
Wharton’s jelly is the gelatinous connective tissue of the umbilical cord and contains a high amount of mesenchymal stem cells.
- It is obtained non-invasively (from postnatal waste tissue).
- It has a high cell yield.
- Wharton’s jelly-derived mesenchymal stem cells are the youngest, most viable, and most potent regenerative cells obtained from the miraculous moment of birth.
- These cells, which are unaged, environmentally undamaged, genetically stable, and compatible with the immune system, carry nature’s purest potential for renewal.
- They have very strong immunomodulatory and anti-inflammatory effects.
Quality Control Parameters (Wharton’s Jelly-Derived Mesenchymal Stem Cells)
- Culture Analysis
- Endotoxin Analysis
- Cell Count and Viability Analysis
- Telomerase Activity Assay Analysis
- Surface Marker Analysis
- Gene Expression Analysis
- Mycoplasma Analysis
- Gram Stain Analysis